Can Nasal Polyps Return after Surgery ?
Nasal polyps affects more than 10% of the population in western countries, 12% in the United States;6 11% in the Europe and 8-11% in Asia.Chronic rhinosinusitis with nasal polyps (CRSwNP), a phenotype of CRS, is a persistent inflammatory disease of the paranasal sinuses, and in 10%-70% accompanied by asthma. Nasal polyps is affecting more than 4% of the population, with about a third of patients not controlled with the current standard of care approach, consisting of topical and systemic glucocorticosteroids (GCS), antibiotics and (often repeated) sinus surgery. In the last 15 years, several randomized double-blind studies on monoclonal antibodies in Nasal Polyps were performed. These studies demonstrated for the first time that biologics targeting type 2 immune reactions might be successful in nasal polyps. The target proteins, interleukin (IL)-4, IL-5, IL-13, and IgE were previously identified as key mediators in studies using nasal polyp tissues to measu...